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Japanese iPSC On the Cusp of a Stem Cell Revolution: Research Turns to Clinical ApplicationsTsukasaki Asako

In the decade since Nobel laureate Yamanaka Shin’ya of Kyoto University created the first human iPS cells, the pioneering technology has emerged as an important new tool in drug development, offering hope for patients with rare and untreatable diseases. Tsukasaki Asako reports on recent triumphs and ongoing challenges.

Kyoto University, Others Eye Clinical Trial of Drug Found with iPS Cell Use (News)

Kyoto, Aug. 1 (Jiji Press)—Kyoto University said Tuesday that it and three other major Japanese universities are slated to conduct the world's first clinical trial of a drug candidate discovered with the use of induced pluripotent stem (iPS) cells. A team at Kyoto University's Center for iPS Cell Research and Application, or CiRA, has examined whether and how each of 6,809 chemical compounds wo…

Japan Team Conducts World’s First Transplant of Donor iPS Cells (News)

Kobe, March 28 (Jiji Press)—A team led by Japanese government-affiliated research institute Riken said Tuesday that it has carried out the world's first surgery to transplant into a patient retina cells created from donor iPS cells. By using a stockpile of induced pluripotent stem cells at Kyoto University, not iPS cells made from the patient's own mature cells, the team, including Kobe City Me…

The Promise of Regenerative MedicineTsukasaki Asako

In August 2006 Professor Yamanaka Shin’ya of Kyoto University published a paper reporting his success in producing induced pluripotent stem cells, and in a 2014 clinical study, tissue derived from iPS cells was transplanted to a patient for the first time. While a host of challenges must be overcome, the promise of regenerative therapies appears to be coming within reach.

Timeline for September 2014

Japan’s second-highest active volcano erupts, causing dozens of fatalities, Indian Prime Minister Narendra Modi visits Japan, and Nishikori Kei reaches the US Open Tennis Championships final. Here are the main news stories for September 2014.

Nobel Selection, Noda RejectionShiraishi Takashi

Yamanaka Shin’ya, a professor at Kyoto University, has been selected as one of the recipients of the 2012 Nobel Prize in Physiology or Medicine for the discovery that mature cells can be reprogrammed to become pluripotent, a finding that holds tremendous promise for the development of regenerative medicine. This is splendid news, and I extend my heartfelt congratulations to Professor Yamanaka. …

Kyoto University CiRA: Japan’s Leading Stem Cell Research Center

Induced pluripotent stem cells known as iPS cells have two crucial abilities: they can differentiate into the cells that build many of the body’s tissues and organs, and they can proliferate almost indefinitely. Established in April 2010, the Center for iPS Cell Research and Application (CiRA) at Kyoto University has been studying these cells and conducting cutting-edge research into their potential use in regenerative medicine.

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